Tirzepatide is a prescription injectable medication given once weekly under the skin (subcutaneously) that acts as a dual hormone agonist. It mimics both glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), two gut hormones involved in regulating insulin release, appetite, and metabolism. This dual action helps improve blood sugar control in adults with type 2 diabetes and, when prescribed in appropriate doses along with diet and exercise, promotes significant weight loss. Its mechanism can also help reduce hunger, slow gastric emptying, and support improved insulin sensitivity. Like all medications, it must be administered under medical supervision and may cause common side effects such as nausea, vomiting, constipation, or abdominal discomfort as the body adjusts.
Semaglutide is a prescription injectable medication administered once weekly under the skin that belongs to the GLP-1 receptor agonist class. It mimics the body’s natural GLP-1 hormone, which stimulates insulin secretion, suppresses glucagon release, slows gastric emptying, and reduces appetite. Semaglutide is FDA-approved for improving blood sugar control in adults with type 2 diabetes and, in higher doses, for long-term weight management when used with diet and exercise. It also has cardiovascular benefit indications in people with type 2 diabetes and established heart disease. Common side effects include nausea, vomiting, diarrhea, and stomach discomfort as the body adapts to the medication.
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